Ainprose™
Our clinic offers therapy using Ainprose™ with strict quality control across all stages from manufacturing to clinical application.
Ainprose™
When stem cells are cultured, they release various types of bioactive proteins, including growth factors.
Ainprose™ is a type of liquid (supernatant) that contains a high volume of growth factors that were produced through culturing of stem cells. Recent studies reveal that various bioactive substances, such as growth factors secreted by stem cells, can promote tissue regeneration by acting on cells already inside the body which have high regenerative potential.
Expectations are high for the benefits of this therapy.
Relief for Many Symptoms
- Bone, Muscle, Joint Symptoms
- Gout
- Hernia
- General stiffness (stiff back)
- Stiff shoulders
- Frozen shoulders
- Strained back
- Bone fractures
- Torn muscles
- Heberden's nodes
- Wrist tendonitis
- Neurological Symptoms
- Numbness
- Motor paralysis
- Sensory abnormalities
- Diabetic neuropathy
- Dementia
- Systemic Symptoms
- Headaches
- Brain fog
- Fatigue
- Dizziness/lightheadedness
- Insomnia/night sweats
- Chronic pain
- Rheumatic diseases
- Promote wound healing
- Improve post-op after effects
- Poor immunity
- Swelling
- Hangovers
- Vascular Symptoms
- Arrhythmia
- Peripheral circulation disorders
- Arteriosclerosis
- Myocardial infarction
- Cerebral infarction
- Vision Symptoms
- Eye strain
- Impaired vision
- Presbyopia
- Floaters
- Diabetic retinopathy
- Skin Symptoms
- Rough skin
- Vitiligo
- Rashes
- Burn scars
- Liver Pancreas Symptoms
- Dyslipidemia
- High blood sugar
- Respiratory Symptoms
- Pneumonia
- Asthma
- Urological Symptoms
- Frequent urination
- Urinary incontinence
- Erectile dysfunction (ED)
- Gynecological Symptoms
- Infertility
- Menopausal disorder
※This therapy is not covered by health insurance.
※The fees below are for patients with Japanese fluency (no medical interpretation required).
※Fees for consultation only: Initial visit fee: ¥16,500 (incl. tax) (¥15,000 ex. tax), [Follow-up visit fee: ¥5,500 (incl. tax) (¥5,000 ex. tax)] + Consultation fee per additional 15 minutes: ¥3,300 (incl. tax) (¥3,000 ex. tax)
[Contact] Sinclair Ginza Clinic
4F; 5F FPG Links Ginza, 2-8-19 Ginza, Chuo-ku, Tokyo, 104-0061 Phone: 03-3538-6082 Email: info@s-gc.jp Website: https://s-gc.jp/eng
Original Cell Culturing & Processing Facility
Sinclair Ginza Clinic provides treatment using Ainprose™ ,
manufactured at our original cell culturing and processing facility.
Comparing Stem Cell Therapy and Ainprose™ Therapy
It is believed that a human body is composed of over 50 trillion cells.
Stem cells are the undifferentiated base cells which can regenerate cells damaged by aging, injury, or disease.
Stem cell therapy cultures and proliferates the stem cells of a patient in a lab, and returns those cells to the body to regrow tissue and treat various diseases.
Ainprose™ is a liquid (supernatant) created by extracting stem cells from a culture medium, and applying multiple stages of processing, including sterilization. Recent studies have revealed more than 500 types of bioactive proteins such as growth factors and cytokines secreted by stem cells, which can stimulate cells inside the body which have high regenerative potential. They are anticipated to be an effective tool to promote the regeneration of tissue.
Expected Benefits of Ainprose™
- Vascular Regeneration
and Angiogenesis - Collateral angiogenesis for interrupted blood circulation due to atherosclerosis
- Nerve Cell Repair
and Regeneration - Repair of peripheral nerves
- Anti-Inflammation Effects
- Promotes healing of damaged areas (injury and inflammation) and reduces pain
- Anti-Oxidant Effects
- Recovery from fatigue, prevention of lifestyle diseases
- Immune System Regulation
- Allergies and sensitivities
- Cosmetic Effects
- Improve wrinkles and sagging with tissue repair actionby repairing tissue
Expected Effects of Growth Factors in Ainprose™
- EGF
(Epidermal Growth Factor) - These growth factors are composed of amino acids that promote the production of new cells, which can act on various cells to encourage growth of cells, regulate proliferation, and make repairs.
- VEGF
(Vascular Endothelial Growth Factor) - These growth factors play a key role in angiogenesis and induce cell division and differentiation, which causes the formation of new blood vessels that branch off from existing ones.
- TGF-β
(Transforming Growth Factor) - These growth factors regulate cell proliferation, growth, differentiation, and motility, playing key roles in the reconstruction, wound healing, inflammation, and immunity of cellular tissues.
- HGF
(Hepatocyte Growth Factor)) - These growth factors promote the proliferation of hepatocytes involved in the synthesis and storage of proteins, the conversion of carbohydrates, and the detoxification, denaturation, and elimination of cholesterol and xenobiotics.
- KGF
(Keratinocyte Growth Factor)) - These growth factors are mitogenic (induce cell division) with angiogenesis and wound healing effects, which assist in the production of keratin, an essential ingredient the formation of hair and skin.
- IGF
(Insulin Growth Factor)) - These growth factors are produced by the growth hormone which is secreted in large quantities during puberty. They function in a variety of ways, including the promotion of cell proliferation/differentiation, and protein assimilation.
- PDGF
(Platelet-Derived Growth Factor) - These growth factors are produced by various cells such as epithelial and endothelial cells. They are involved in regulating the migration and proliferation of mesenchymal cells, which helps promote the growth and regeneration of damaged tissues.
- FGF
(Fibroblast Growth Factor) - These growth factors are involved in angiogenesis and wound healing.
They play key roles in the proliferation and differentiation of a wide range of cells and tissues.
- IL-7
(Interleukin-7)) - These regulating factors are bioactive substances that promote cell proliferation, and are keys to the survival, proliferation and maturation of cells.
- GM-CSF
(Granulocyte-Monocyte Colony-Stimulating Factor)) - These growth factors promote cell survival and activation. They are hematopoietic growth factors that promote the differentiation into pluripotent hematopoietic stem cells and function as immunoregulatory factors.
- EPO
(Erythropoietin)) - These growth factors are mainly produced in the kidneys, and are one of the hematopoietic factors that promote the production of red blood cells.
- TSG-6
(Anti-Inflammatory Factor) - These growth factors are gaining attention for suppressing inflammation, and as a treatment for arteriosclerosis.
- TPO
(Thrombopoietin)) - These hematopoietic factors are involved in the proliferation and differentiation of proplatelets, and are considered to be key factors in the production of hematopoietic cells.
- TIMP
(Tissue Inhibitor of Metalloproteinase) - MMP Inhibits the degradation of tissue collagen and elastin by MMPs, and helps prevent fibrosis.
※MMPs (matrix metalloproteinases) are enzymes that degrade intercellular proteins such as collagen, proteoglycans, and elastin. Abnormal MMPs are said to be correlated with the development of problems including cancer, inflammation, multiple sclerosis, and gum disease.
Safety of Ainprose™
- Manufactured in a strictly controlled facility
- Sterilization in clean rooms and prevention of contamination
- Strict quality control is ensured through four safety tests
- Human Virus Tests
- We test for human viruses (HIV1, HIV2,HCV, HBV, HTLV1&2, Parvovirus B19)according to the recommendations of the Guidelines for the Quality and Safety of Cellular Therapeutic Products.Nucleic acids are extracted from the cells collected by centrifugation of the test sample using the DNA/RNA simultaneous collection procedure with NucleoSpin RNA. The presence of a particular virus is determined by reverse transcription/real-time PCR using primer/probe sets specific for each virus sequence.
- Sterility Test
- This tests for aerobic bacteria such as molds that grow during the culturing process, as well as anaerobic bacteria that do not require oxygen.The microbial detection system BACT/ALERT is used to test sterility. Sterility is determined according to bacterial growth after culturing the test sample in the test medium at 32.7°C for seven days.
In addition, a inhibitory effect confirmation test is performed using the test sample in a test medium inoculated with multiple varieties of standard bacteria. It is cultured in the same process as the test sample, and the growth of standard bacteria or lack of inhibition is confirmed
- Mycoplasma Test
- Mycoplasma are the smallest microorganisms that can self-proliferate. They are classified as bacteria and are known to cause pneumonia and other diseases.
These bacteria are difficult to observe due to their size and lack of cell walls.
Using the MycoSEQ Mycoplasma Detection Kit, DNA is extracted from the sample/positive control sample DNA to determine the presence of mycoplasma through real-time PCR testing using mycoplasma-specific primers.
- Endotoxin Test
- Endotoxins are a type of pyrogen (fever-inducing substance) with bioactive properties including exothermic effects and lethal toxicity.
The sample is added to an Endosafe-PTS Cartridge JP and measured using the endotoxin analyzer. Each cartridge includes standard endotoxins to serve as indicators to measure the recovery rate of the added standard endotoxins, and the concentration level of the sample
Doctor introduction
MEDICAL MENU
Holders of a Japanese health insurance card or a resident card in Japan
Adjunctive Therapy Featuring Ainprose™ (Intravenous Infusion / Intravenous Injection)
- Intravenous infusion
-
Ainprose™ 30mL: 1 treatment
¥450,000 w/o tax
（495,000 yen (including tax)）
- Intravenous infusion
-
Ainprose™ 30mL: 3 treatments
¥1,215,000 w/o tax
（1,336,500 yen (including tax)）
※Therapy Period: 1 year from the day therapy starts
- Intravenous infusion
-
Ainprose™ 30mL: 6 treatments (+1)
¥2,250,000 w/o tax
（2,475,000 yen (including tax)）
※Therapy Period: 2 years from the day therapy starts
- Intravenous infusion
-
Ainprose™ 10mL: 1 treatment
¥205,000 w/o tax
（225,500 yen (including tax)）
- Intra-articular Injection
-
Ainprose™ 5mL: 1 treatment
¥115,000 w/o tax
（126,500 yen (including tax)）
Adjunctive Therapy Featuring Ainprose™ (Targeted Administration)
- Intra-articular Injection
-
Ainprose™ Treatment: 1 location
¥90,000 w/o tax
（99,000 yen (including tax)）
- Ultrasonic Penetration
-
Ainprose™ Treatment: 2mL
¥58,000 w/o tax
（63,800 yen (including tax)）
- Ultrasonic Penetration
-
Ainprose™ Treatment：1mL
¥43,000 w/o tax
（47,300 yen (including tax)）
Those who do not have a Japanese health insurance card or a resident card in Japan
Adjunctive Therapy Featuring Ainprose™ (Intravenous Infusion / Intravenous Injection)
- Intravenous infusion
-
Ainprose™ 30mL: 1 treatment
¥671,000(including tax)
- Intravenous infusion
-
Ainprose™ 30mL: 3 treatments
¥2,013,000(including tax)
Re:A Set of 4 cosmetics + Supplement
※Therapy Period: 1 year from the day therapy starts
- Intravenous infusion
-
Ainprose™ 30mL: 6 treatments (+1)
¥4,026,000(including tax)
Re:A Set of 4 cosmetics + Supplement
Ainprose™ 30mL: 1 additional treatment valued at ¥671,000 added at no extra cost.
※Therapy Period: 2 years from the day therapy starts
- Intravenous infusion
-
Ainprose™ 10mL: 1 treatment
¥308,000(including tax)
- Intra-articular Injection
-
Ainprose™ 5mL: 1 treatment
¥170,500(including tax)
Adjunctive Therapy Featuring Ainprose™ (Targeted Administration)
- Intra-articular Injection
-
Ainprose™ Treatment: 1 location
¥134,200(including tax)
- Ultrasonic Penetration
-
Ainprose™ Treatment: 2mL
¥86,900(including tax)
- Ultrasonic Penetration
-
Ainprose™ Treatment：1mL
¥64,900 (including tax)
[Therapy Offered] Mesenchymal Stem Cells - Conditioned Medium Therapy
*This therapy is not covered by health insurance.
*Fees for consultation only: Initial visit fee: ¥16,500 (incl. tax) (¥15,000 ex. tax), [Follow-up visit fee: ¥5,500 (incl. tax) (¥5,000 ex. tax)] + Consultation fee per additional 15 minutes: ¥3,300 (incl. tax) (¥3,000 ex. tax)
*General therapy fees: Minimum cost: ¥47,300 (incl. tax) (¥43,000 ex. tax), Maximum cost: (6 sessions): ¥2,475,000 (incl. tax) (￥2,250,000 ex. tax)
*General therapy frequency & fees: [Ainprose™ liquid] Once every two weeks to once a month, Session fee: ¥495,000 (incl. tax and initial visit fee) (¥450,000 ex. tax)
[Ainprose™ topical administration] Once a month to once two months, Session fee: ¥99,000 (incl. tax and initial visit fee) (¥90,000 ex. tax)
*The fees above are for patients with Japanese fluency (no medical interpretation required).
*One of the risks associated with this therapy is that the administration of the stem cell culture supernatant may cause side effects such as temporary allergies.
*Stem cell culture supernatant is not a pharmaceutical product approved under the PMD Act.
*In Japan and other countries, there is no definitive information on the potential for serious risks associated with stem cell culture supernatant.
*There is no other approved pharmaceutical product in Japan with the same ingredients and functions as stem cell culture supernatant.
Map/Hours
Sinclair Ginza Clinic
4F & 5F FPG Links Ginza, 2-8-19 Ginza, Chuo-ku, Tokyo, 104-0061
Ginza-itchome Station [Exit 9]: 1 minute walk
Ginza Station [Exit A13]: 4 minutes walk
Higashi-ginza Station [Exit A8]: 6 minutes walk
JR Yurakucho Station [Kyobashiguchi Exit]: 7 minutes walk
| Clinic Hours | Mon | Tue | Wed | Thu | Fri | Sat | Sun |
|---|---|---|---|---|---|---|---|
| 10:00 AM to 1:00 PM | 〇 | 〇 | Closed | 〇 | 〇 | 〇 | Closed |
| 2:00 PM to 7:00 PM | 〇 | 〇 | Closed | 〇 | 〇 | 〇 | Closed |
Last Check-in: 6:00 PM
